|
KMID : 1149220100180010121
|
|
Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 1 p.121 ~ p.132
|
|
|
Study on the Anti-inflammatory Effects of the Remedy Prescripted with Lonicerae Flos and Scutellariae Radix in U937 cells
|
|
Lee Yong-Suk
Jang Seon-Il
|
|
|
Abstract
|
|
|
|
Inflammatory reaction is characterized by over-production of inflammatory mediators due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1beta (IL-), IL-6, tumour necrosis factor alpha (TNF-), prostaglantin (), and nitric oxide (NO) in U937 cells. We investigate the anti-inflammatory effects of water extracts from Lonicerae Flos and Scutellariae Radix in lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-, TNF-, and ) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. Their combination extract also inhibited NF--DNA complex of NF- binding activity and translocation of NF- from cytosol to nucleus. These results suggest that the combination of water-extractable components of Lonicerae Flos and Scutellariae Radix may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
|
|
|
KEYWORD
|
|
|
Lonicerae Flos, Scutellariae Radix, Pro-inflammatory mediators, Anti-inflammatory
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|